Inflammation and Arthritis

Arthritis, accustomed to affect the over 40s but nowadays children at the age of fifteen are beginning to be affected by it. There are numerous forms of arthritis but we will be looking at the three most widespread.

Osteoarthritis

Also known as degenerative arthritis, Osteoarthritis is the most prevalent kind of arthritis and it occurs when the protective cartilage within the edges of your bones wears down. It is the results from joint cartilage failure activated by a combination of genetic, metabolic, biochemical and biomechanical factors. This disease is normally addressed with analgesics, for example, acetaminophen and opioids, NSAIDs, glucocorticoids and hyaluronans.

Rheumatoid arthritis is an autoimmune ailment that triggers chronic inflammation of the joints. Autoimmune diseases are illnesses that develop when the body is erroneously attacked by its own defense mechanisms. Rheumatoid arthritis could also cause inflammation of the tissue around the joints, along with other internal organs in your body. The reaction affects several organs in the body which is known as a wide spread disorder and is typically called rheumatoid condition.

Hormones are important in the study of the factors behind this disease as 75% of the victims are ladies. Cigarette smoking and stress are also regarded as contributor to this disease. The remedy consists of medications such as acetaminophen and opioids, NSAIDs, glucocorticoids and anti-rheumatic drugs (DMARDs). However, these agents may generate several side effects.

Gout

Gout is a disease which is a form of arthritis that occurs when urates accumulates in blood and results in joint inflammation. This excess of uric acid results in the development of tiny crystals of urate that deposit in tissues of the body, particularly the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation – arthritis.

It is normally addressed with non-steroidal anti-inflammatory drugs (NSAIDs), colchicines or glucocorticoids. Treatment with the drugs normally may cause severe side effects.

Curcumin Anti-Inflammatory Arthritis Treatment

Knowing the underlying causes of arthritis allows physicians to conduct the necessary treatment method which include selecting for the appropriate medicinal drug to suppress the inflammation in Osteoarthritis, Rheumatoid Arthritis,  or Gout patients – arthritis treatment. A significantly better option would be to decide on herbal supplements to deal with and treat the pain and swelling caused by arthritis.

Curcumin for Arthritis Treatment

Most arthritis diseases are predominantly caused by inflammation and the deterioration of cartilages. The inflammation and cartilage degeneration are induced by interleukins. In herbal arthritis treatment, curcumin’s  anti-inflammatory property is used to reduce or protect against interleukins from promoting the inflammation. Thus, a Curcumin Anti-Inflammatory arthritis treatment to treat arthritis diseases is very promising.

 

References

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Deodhar, S.D., Sethi, R., Srimal, R.C. (1980).Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J. Med. Res. 71:632-634
Funk, J.L., Oyarzo, J.N., Frye, J.B., Chen, G., Lantz, R.C., Jolad, S.D., et al. (2006). Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J. Nat. Prod. 69:351-355
Hak, A.E., Choi, H.K. (2008). Lifestyle and gout.Curr.Opin.Rheumatol. 20:179-186
Jackson, J.K., Higo, T., Hunter, W.L., Burt, H.M. (2006). The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm. Res. 55:168-175
Joe, B., Rao, U.J.S.P., Lokesh, B.R.(1997). Presence of an acidic glycoprotein in the serum of arthritic rats:modulation by capsaicin and curcumin. Mol. Cell Biochem. 169:125-135
Khanna, D., Sethi, G., Kwang, S.A., Pandey, M.K., Kunnumakkara, A.B., Sung, B., Aggarwal, A., Aggarwal, B.B. (2007). Natural products as a gold mine for arthritis treatment.Current Opinion in Pharmacology. 7:344-351
Lev-Ari, S., Strier, L., Kazanov, D., Elkayam, O., Lichtenberg, D., Caspi, D., Arber, N. (2006).Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology (Oxford). 45:171-177.
Liacini, A., Sylvester, J., Li, W.Q., Huang, W., Dehnade, F., Ahmad, M., Zafarullah, M. (2003). Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, chondrocytes. Exp. Cell. Res. 288:208-217
Onodera, S., Kaneda, K., Mizue, Y., Koyama, F., Fujinaga, M., Nishihira, J. (2000). Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. J. Biol. Chem. 275:444-450
Park, C., Moon, D.O., Choi, I.W., Choi, B.T., Nam, T.J., Rhu, C.H., Kwon, T.K., Lee, W.H., Kim, G.Y., Choi, Y.H. (2007). Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. Int. J. Mol. Med. 20:365-372
Sale, J.E., Gignac, M., Hawker, G. (2008).The relationship between disease symptoms, life events, coping and treatment, and depression among older adults with osteoarthritis. J. Rheumatol. 35:335-342
Shakibaei, M., John, T., Schulze-Tanzil, G., Lehmann, I., Mobasheri, A. (2007).Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: implications for the treatment of osteoarthritis. Biochem.Pharmacol. 73(9): 1434-1445
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