Lose Weight With Curcumin Anti-Obesity Agent
According to World Health Organization (WHO), obesity had reached epidemic proportions worldwide. There are more than 300 million obese adults in which 42 million are children. Obesity incidence is now becoming a major health concern as it may facilitate the development of other diseases.
Obesity is described as a phenotypic indication of irregular or excessive fat build-up that changes health and increases fatality. Elements that cause obesity involve metabolism, genetics, diet, physical activity, as well as the socio-cultural surroundings that characterizes the modern day living. It is more widespread for communities currently in an environment described as long term energy positive imbalance due to sedentary lifestyle, low resting metabolic rate or both.
Obesity is strongly linked with numerous serious diseases including diabetes mellitus, high blood pressure, abnormal amount of lipids (cholesterol and/or fat), cardiovascular diseases, lung diseases, and increase risk in Alzheimer’s disease. It is also associated with the increase in formation of a cancerous growth that might contribute towards greater occurrence of abnormal growth of tissue in obese individuals.
Plant Natural Products and Anti-Obesity Agent
The interest in plant natural products had brought scientists to the discovery of the therapeutic effects of the dietary phytochemicals against various diseases. The worrying condition of obesity even encouraged researchers to determine and define plant natural products that could function as anti-obesity agent.
Scientific studies on turmeric has been buzzing globally as this cooking ingredient is used in traditional Ayurvedic medicinal practices and modern scientific laboratory researches has proved that its active component, Curcumin possesses therapeutic effect against various diseases.
In ‘Dietary Phytochemicals and ThCurcumin Anti-Obesity Agenteir Potential Effects on Obesity: A Review’, González-Castejón and Rodriguez-Casado suggested that curcumin is a promising anti-obesity agent. Curcumin may regulate the expression of genes related to energy metabolic process and fat deposition thus decreasing the quantity of intra-cellular lipids. In adipose tissues (body fat), curcumin suppresses angiogenesis, which is essential for tissue growth and together with the effects on lipid metabolic process in adipocytes. Curcumin anti-obesity agent lowers body fat and reduces weight.
Curcumin may also make improvements to obesity-associated inflammation along with other metabolic disorders such as hyperglycemia, insulin resistance, hyperlipidemia, and hypercholesterolemia. A different study indicates that curcumin helps to protect from liver injury preventing Low-Density Lipoproteins (LDL) oxidation by controlling the harmful leptin which helps to regulate energy intake-implicated in liver fibrosis.
An ‘In-Vivo’ study proved that curcumin ameliorates some indicator related to diabetes and leptin-deficiency. Curcumin treatment also significantly decreases macrophage infiltration of white adipose tissue, elevates adipose tissue adiponectic generation and reduces hepatic NF-kB activity and markers of hepatic inflammation. Curcumin also induces reduction of adipogenic differentiation by activation of Wnt/ß-Catenin signalling.
Curcumin also directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, muscles and immune system macrophages thus assists in reducing leptin resistance, enhances adiponectin and lowers various inflammatory indicators associated with obesity which includes TNF-a, IL-6, resistin, leptin and MCP-1.
Curcumin, A Promising Anti-Obesity Agent
Based on the evidences stated earlier, it can be concluded that turmeric’s curcumin is a promising anti-obesity agent which also helps in weight loss. This shows that by bringing out the best from nature, we could have the remedies that might be beneficial as protection and treatment for a variety of conditions faced by mankind.
The search for the Anti-Obesity Agent could probably ends with the discovery of curcumin in the spice turmeric.
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– Lose Weight With Curcumin Anti-Obesity Agent