Curcumin Breast Cancer Treatment

Based on Malaysia National Cancer Council (MAKNA), breast cancer remains the greatest threat among women in Malaysia (MAKNA, 2012). Ries et al. (2007) also stated that breast cancer is the most commonly diagnosed cancer at an average age of 61 years in women. Normally, the whole procedure of tumorigenesis takes place at the age of twenty; unfortunately cancer discovery is usually around 50 years old or later. Curcumin, a turmeric active ingredient could hold the key in breast cancer treatment.

Cucumin Anti-Tumor Property and Breast Cancer Treatment

Remarkably, all-natural plant based solutions may possibly emerge as the source of remedy that is natural, cost-effective and safe in comparison to the chemical based solutions (Anand et al., 2008). One of the plants is Turmeric in which curcumin compound is found, has been used in traditional healing practices and its many benefits are well recognized. Curcumin Anti-tumor property has been proven to hold against numerous abnormal growths which include human breast carcinoma (Duvoix et al., 2005) and several methods have been proposed to account for the action of curcumin in breast cancer cells (Anand et al., 2008).

Curcumin Breast Cancer Treatment Clinical Trials

The administration of curcumin dietary supplement considerably lessened the incidence of mammary abnormal growths (Anand et al., 2008). From the clinical trial explained by Aggarwal et al. (2007), the strength of topical application of curcumin lotion in 7 patients with breast cancer was examined. Seventy-one percent (71%) sufferers showed positive responses that were measured in reduction in lesion size, discomfort, itching and exudation.

In 2010, Bayet-Robert et al. announced that during the phase one clinical trial, a mixture of curcumin and Docetaxel demonstrated favorable effects in breast cancer sufferers with advanced and metastatic breast cancer – curcumin for breast cancer treatment!

Curcumin Anti-tumor Property for Breast Cancer Treatment

Curcumin Anti-tumor property has acquired an exceptional attention for breast cancer treatment. As breast cancer continues to be the leading risk to women, these studies could be regarded as promising for this ‘silent killer’.

References

Aggarwal, B.B., Bhatt, I.D., Ichikawa, H., Ahn, K.S., Sethi, G., Sandur, S.K., Sundaram, C., Seeram, N., Shishodia, S. (2007).Curcumin- biological and medicinal properties, in: Ravindran, P.N., Babu, K.N., Sivaraman, K. (Eds.). Turmeric the Genus Curcuma. CRC Press, NY. Pp. 297-368.
Anand, P., Sundaram, C., Jhurani, S., Kunnumakkara, B. and Aggarwal, B.B.(2008). Curcumin and cancer: An ‘old-age’ disease with an ‘age-old’ solution. Cancer Letters. 267: 133-164.
Anitha, A. et al. (2011). Preparation, characterisation, in vitro drug release and biological studies of curcumin loaded dextran sulphate-chitosan nanoparticles. Carbohyd.Polym. 84: 1158-1164.
Bayert-Robert, M., Kwiatkowski, F., Leheurteur, M., Gachon, F., Planchat, E., Abrial, C., Mouret-Reynier, M.A., Durando., X., Barthomeuf, C., Chollet, P. (2010). Phase 1 dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol. Ther.9(1.).
Duvoix, A., Blasius, R., Delhalle, S., Schnekenburger, M., Morceau, F., Henry, E., Dicato., M., Diederich, M. (2005). Chemopreventive and therapeutic effects of curcumin.Cancer Letters. 223: 181-190.
Fang, H.Y., Chen, S.B., Guo, D.J., Pan, S.Y., Yu, Z.L. (2011). Proteomic identification of differentially expressed proteins in curcumin-treated MCF-7 cells.Phytomedicine. 18: 697-703.
MAKNA.(2012). Malaysia National Cancer Council.
Ries, L.A.G., Melbert, D., Krapcho, M., Mariotto, A., Miller, B.A., Feuer, E.J., Clegg, L., Horner, M.J., Howlader, N., Eisner, M.P., Reichman, M., Edwards, B.K. (Eds.).(2007).SEER Cancer Statistics Review, 1975-2004, National Cancer Institute, Bethesda, MD. Available from: www.seer.cancer.gov/csr/1975-2004/. Based on November 2006 SEER data submission, posted to the SEER website.
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