In Malaysia, heart and lung related diseases were the primary reason behind the 25.35% fatalities in government hospitals (Health Particulars, 2010). The situation has been escalating although preventive measures and proper treatments were made available to curb this alarming trend.
The enthusiasm in curcumin, has guided researchers to an astonishing discoveries on this substance obtained from our cooking item, the turmeric. This active ingredient could have the means to battle medical conditions, including cardiovascular diseases. Inside the pathogenesis of numerous conditions, oxidative stress plays a vital role and there’s where antioxidant is required. Curcumin contains a strong antioxidant activity in comparison to Vitamins E and C (Toda et al., 1985).
Curcumin for cardiovascular diseases treatment was evident when Frey and Olson (2003) mentioned that cardiac hypertrophy is certainly an adaptive enlargement inside the myocardium (heart muscle) addressing the many stresses which would gradually result in heart failure and loss of life (Heineke and Molkentin, 2006). Driven by the review put together by Srivastava et al. (2011), they concluded that curcumin offers an anti-hypertrophic quality which may provide protection against cardiac hypertrophy and heart failure (Li et al., 2008: Morimoto et al., 2008).
Curcumin Cardiovascular Diseases: Heart Attack (Myocardial Infarction)
In myocardial infarction (heart attack) and ischemia/reperfusion, an oxidative stress might be the main outcome determinant. Due to curcumin’s antioxidant property, it has been demonstrated to prevent isoproterenol initiated myocardial necrosis in rats (Manikandan et al., 2004). Additionally, the development of harmful toxins subsequent to ischemia/reperfusion could also be managed by curcumin’s strong antioxidant activity (Srivastava et al., 2011) ideal in cardiovascular diseases treatment.
Curcumin Arterial Disease: Total Cholesterol Lowering
In 1992, Soni and Kuttan had supervised a curcumin’s influence study on serum cholesterol and lipid peroxide levels in 10 healthy volunteers. Curcumin was ingested once daily (500 mg) for 7 days and this led to a significant 33% decrease in serum lipid peroxides, a 29% boost in serum HDL cholesterol, plus a total cholesterol lowering of 12%. This finding might signify the role of curcumin in arterial diseases. In a different study, the administration of curcumin (10 mg) two times daily for four days had lowered serum LDL and elevated serum high-density lipoprotein levels in patients with cardiovascular (Ramirez et al., 2000); another evidence of curcumin potential in cardiovascular diseases treatment
Curcumin Cardiovascular Diseases and Cancer Treatment
A strong medication for the treatment of cancer, Doxorubicin, is a serious concern for cancer sufferers as it is being associated with cardiotoxicity (Doroshow, 1991). Curcumin treatment significantly attenuated the cardiotoxic effects of Doxorubin (Venkatesan, 1998).
As a whole, the above numerous studies have demonstrated the usefulness of curcumin for cardiovascular diseases treatment.
Dikshit, M., Rastogi, L., Shukla, R., Srimal, R.C. (1995). Prevention of ischaemia-induced biochemical changes by curcumin and quinidine in the cat heart. Indian Journal of Medical Research. 101: 31-35
Doroshow, J.H. (1991). Doxorubicin-induced cardiac toxicity. N. Engl. J. Med. 324(12):843-845
Frey, N., Olsen, E.N. (2003). Cardiac hypertrophy: the good, the bad and the ugly. Annu. Rev. Physiol. 65:45-79
Health Facts 2010 (2010).Ministry of Health Malaysia.www.moh.gov.my/v/duk
Heineke, J., Molkentin, J.D. (2006). Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell. Biol. 7(8): 589-600
Li, H.L., Liu, C., de Couto, G., et al. (2008).Curcumin prevents and reverses murine cardiac hypertrophy. J. Clin. Invest. 118(3):879-893
Manikandan, P., Sumitra, M., Aishwarya, S., Manohar, B.M., Lokanadam, B., Puvanakrishnan, R. (2004).Curcumin modulates free radical quenching in myocardial ischaemia in rats. International Journal of Biochemistry and Cell Biology. 36(10): 1967-1980
Marcu, M.G., Jung, Y.J., Lee, S. et al. (2006). Curcumin is an inhibitor of p300 histone acetylatransferase. Med. Chem. 2(2): 169-174
Morimoto, T., Sunagawa, Y., Kawamura, T., et al. (2008). The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J. Clin. Invest. 118(3): 868—878
Motterlini, R., Foresti, R., Bassi, R., Green, C.J. (2000). Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radical Biology and Medicine. 28(8): 1303-1312
Nirmala, C., Puvanakrishnan, R. (1996a). Effect of curcumin on certain lyosomal hydrolases in isoproterenol-induced myocardial infarction in rats.Biochemical Pharmacology. 51(1): 47-51
Nirmala, C., Puvanakrishnan, R. (1996b). Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Molecular and Cellular Biochemistry. 159(2): 85-93
Rajagopalan, S., Politi, P.M., Sinha, B.K., Myers,C.E. (1988). Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity. Cancer Res. 48(17): 4766-4769
Ramirez Bosca, R. Soler, A., Carrison-Gutierrez, M.A., Pamies Mira, D., Pardo Zapata, A., Diaz-Alperi, J. (2000).Anhydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen. Mech. Ageing Dev. 114:207-210
Reddy, A.C., Lokesh, B.R. (1992).Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes.Molecular and Cellular Biochemistry. 111(1-2): 117-124
Reddy, A.C., Lokesh, B.R. (1994).Studies on the inhibitory effects of curcumin and eugenolon the formation of reactive oxygen species and the oxidation of ferrous ion.Molecular and Cellular Biochemistry. 137(1): 1-8
Soni, K.B., Kuttan, R. (1992). Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers.Indian J. Physiol. Pharmacol. 36: 273-275
Sreejayan, Rao, M.N. (1994). Curcuminoids as potent inhibitors of lipid peroxidation.Journal of Pharmacy and Pharmacology. 46(12): 1013-1016
Sreejayan, Rao, M.N. (1997). Nitric oxide scavenging by curcuminoids.Journal of Pharmacy and Pharmacology. 49(1): 105-107
Srivastava, R.M., Singh, S., Dubey, S.K., Misra, K., Khar, A. (2011). Immunomodulatory and therapeutic activity of curcumin.International Immunopharmacology. 11:331-341
Toda, S., Miyase, T., Arichi, H., Tanizawa, H., Takino, Y. (1985).Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L. Chemical and Pharmaceutical Bulletin. 33(4): 1725-1728.
Unnikrishnan, M.K., Rao, M.N. (1995). Curcumin inhibits nitrogen dioxide induced oxidation of haemoglobin. Molecular and Cellular Biochemistry. 146(1):35-37
Venkatesan, N. (1998). Curcumin attenuation of acute Adriamycin myocardial toxicity in rats. Br. J. Pharmacol. 124(3):425-427
Yeh, P.Y., Chuang, S.E., Yeh, K.H., Song, Y.C., Chang, L.L., Cheng, A.L. (2004). Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death. Oncogene. 23(20): 3580-3588
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