Colorectal Cancer Treatment

Turmeric-Curcumin And Colorectal Cancer Treatment

Colon is a segment of the large intestine that plays an important role in the body’s ability to digest food and pass waste. However, the cells may also develop cancer. Colorectal cancer is also known as a bowel cancer; the cancer of the colon and rectum.

A 2006 Malaysian cancer statistics showed that colorectal cancer is the second most common cancer after breast cancer and the first among male and second among female in Peninsular Malaysia. According to the National Cancer Registry, Chinese have the highest incidence of colon and rectal cancers.  There  were  59.8%  of  cases  involved  Malaysian  Chinese  followed  by  Malay  with 34.6% cases and Indian with 5.6% of cases.

In this article we will be discussing the potential of Curcumin in Colorectal Cancer Treatment.

Curcumin’s Therapeutic Agent

Curcumin is a spice common to India and it is derived from the rhizome of Curcuma longa. The active compound of curcumin known as curcuminoids possesses yellowish-orange color. Nowadays, curcumin has been studied in a broad area including antioxidant potential, Alzheimer’s disease, inflammation, chemoprevention, and chemotherapy (J.J. Johnson and H. Mukhtar,2007).

Researches using various colorectal cell lines have proven curcumin as a therapeutic agent and able to act through numerous target molecules. Studies of curcumin by Chin et. al. (2006) showed that curcumin inhibits cell migration of human colon cancer Colo 205 cells through the inhibition of nuclear factor kappa B/p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions.

Researches on Curcumin Colorectal Cancer Treatment

Several in-vivo studies sighted chemo-preventive ability as well as anticancer activity of curcumin against colorectal cancer. Dietary curcumin (0.2%) inhibited the formation of carcinogen-induced colorectal tumors in rats (Wijnands et. al., 2004). Other studies evaluated the effect of curcumin on azoxymethane (AOM) induced colon cancer in animal model and showed a significant inhibition of colon carcinogenesis after the treatment with curcumin (Goel et. al., 2007).

The in-vivo studies also compared the efficacy of liposomal curcumin (40 mg/kg adminis-teredi.v.) with that of oxaliplatin, a standard chemotherapeutic agent for colorectal cancer and showed that the significant tumor growth inhibition was observed in Colo205 and LoVoxenograft models in mice.(Li et. at., 2007).

Clinical Studies

Clinical studies on pharmacodynamic and pharmacokinetic effect of oral curcumin in fifteen patients with advanced colorectal cancer refractory to standard chemotherapies received curcumin daily for up to 4 months was evaluated. The results showed that oral curcumin extract was well tolerated, and dose limiting toxicity was not observed (Goel et. al., 2007).

Curcumin Potentials for Colorectal Cancer Treatment

In-vitro, in-vivo, and human clinical studies have all established curcumin’s potentials and has also revealed curcumin therapeutic benefits include colorectal cancer treatment. The safety, low cost, and proven efficacy of this ‘‘age-old” natural alternative therapy makes it a promising agent for the treatment of an ‘‘old-age” disease such as cancer.



A. Goel, A.B. Kunnumakkara, B.B. Aggarwal, Curcuminas Curecumin: from kitchen to clinic, Biochem. Pharmacol.(2007).
B.B. Aggarwal, A. Kumar, A.C. Bharti, Anticancer potentialof curcumin: preclinical and clinical studies, Anticancer Res.23 (2003) 363–398
Chin-Cheng Su, Guang-Wei Chen, Jaung-Geng Lin, Lii-Tzu WuAnd Jing-Gung Chung.Curcumin Inhibits Cell Migration of Human Colon CancerColo 205 Cells through the Inhibition of Nuclear Factor kappa B /p65 and Down-regulates Cyclooxygenase-2 andMatrix Metalloproteinase-2 Expressions. Anticancer Research26 : 1281-1288 (2006).
J.J. Johnson and H. Mukhtar, Cancer Letters 255 (2007) 170–181
L. Li, B. Ahmed, K. Mehta, R. Kurzrock, Liposomalcurcumin with and without oxaliplatin: effects on cellgrowth, apoptosis, and angiogenesis in colorectal cancer,Mol. Cancer Ther. 6 (2007) 1276–1282.
M.V. Wijnands, M.J. van Erk, R.P. Doornbos, C.A. Krul,R.A. Woutersen, Do aberrant crypt foci have predictivevalue for the occurrence of colorectal tumours? Potential ofgene expression profiling in tumours, Food Chem. Toxicol.42 (2004) 1629–1639
National Cancer Registry, Ministry of Health Malaysia (2006) ISBN 978-983-3433-51-3 (
National Cancer Patient Registry-Colorectal Cancer and Clinical Research Centre (CRC), November 2010 (



There is no related post found.
(Visited 112 times, 1 visits today)

, , , , , , ,


  1. Alarming News » Blog Archive » Letting Cancer Know That It Is Not Welcome In Your Life - July 19, 2013

    […] will be at noticing any differences. Be cautious about chemical contamination on fresh fruits and vegetables from the store. Pesticides are used to prevent insects and other issues from causing […]

  2. Maryannaville » Archiwum Bloga » Don’t Be Overwhelmed By Cancer; Read This - July 21, 2013

    […] detection is the key to overcoming any cancer. Talk with upper throat cancer treatment your doctor and set up regular times for screenings to best eliminate the chance for early cancer […]

  3. Reality On Bravo » Blog Archive » Dominos Pizza - August 14, 2013

    […] cheese and tomato ones in Asda were so-so but not a patch on Dominos). BTW – I did do a search but blog didn’t find ‘owt. For the original version including any supplementary images or video, […]

  4. Reality On Bravo » Blog Archive » Wisconsin Approves 13 Insurers for Marketplace - August 19, 2013

    […] Health Plans Insurance Corp.Arise (WPS Health Plan Inc.)Nine companies also won initial approval to sell insurance plans in the small business Marketplace. They are:Common Ground Healthcare […]

  5. Reality On Bravo » Blog Archive » Tips To Help You Deal With Cancer - August 24, 2013

    […] can really help you when you are experiencing cancer yourself or assisting a loved one who is. The article below has the kind of advice that will help you be more confident in handling this […]

  6. Use Of Low-dose Steroid Creams During Pregnancy Won’t Affect Baby: Study | Design Mom - September 8, 2013

    […] creams are often preferred.The finding that steroid creams given at a high dose may have some link cucumin extract supplement to an increased risk of low birth weight is especially important, he said.”My […]

  7. Reality On Bravo » Blog Archive » Understand Cancer And What You Can Do With These Tips - September 8, 2013

    […] motivate you to make better decisions. Use the tips that you will read to better cope with cancer, check it out and spend some time applying the advice that will be given to you.Eliminating sugar from your diet […]

  8. Maryannaville » Archiwum Bloga » Understand Cancer And What You Can Do With These Tips - September 18, 2013

    […] excellent that they want to help you. You must consider what you plan to say to each person, and word it in a way that will be non-confrontational. Times like these are extremely difficult for […]

  9. Our Gaggle Of Girls : Tips On How To Effectively Fight Cancer - October 31, 2013

    […] with cancer, you have to read whatever you can on this topic. It’s crucial to have a high level of confidence.Depression often causes health issues of its own, which can lead to […]

  10. Alarming News » Blog Archive » Know The Risk Factors For Malignant Melanoma - November 11, 2013

    […] for: Asymmetry (the mole cannot be evenly folded in half); Borders (irregular or jagged borders clicking here are more common with melanoma); Color (if there are several colors in the lesion, you should have […]

  11. Reality On Bravo » Blog Archive » Scorpion Venom Treatment May Offer False Hope To Cancer Patients - November 11, 2013

    […] [a] natural product.” Medolife breeds a giant colony of scorpions — 83,000 strong at a curcumin colorectal cancer treatment scorpion reservation in the Dominican Republic. Turn over any rock, or peer down a bamboo segment […]

  12. Our Gaggle Of Girls : Preventing Breast Cancer - November 19, 2013

    […] cancer. Male breast cancer, prostratic and pancreatic cancer appear to be more strongly related to the BRCA 2 mutation. Other genetic mutations such as TP53, PTEN, STK11/LK B1 are also […]

  13. Alarming News » Blog Archive » Prostate Cancer May Respond To A Low-fat Diet - November 23, 2013

    […] treatment is the best option for them. That is the same with those who test negative, since it curcumin colorectal cancer treatment has yet to be proven keeping these patients under active surveillance doesnat put them at risk. But […]

  14. Positive Phase 2 Results From Agenus’ Brain Cancer Vaccine Published In Neuro-oncology | The Disney Traveler - December 17, 2013

    […] cancer treatment Partners with Three New bowel cancer symptoms Cancer Centers to Provide Genetic […]

  15. What’s Really In Turmeric Supplements And Spices? You May Not Want To Know | The Disney Traveler - December 20, 2013

    […] has been previously been suggested to have many health benefits with data from cell cultures and curcumin colorectal cancer treatment experimental animals models suggesting the spice extract has beneficial actions for lipid […]

  16. Regular Colonoscopies May Cut Colorectal Cancer Risk By 40 Percent - Mrs. Fussypants Guide To Life - December 29, 2013

    […] a stronger link when it came to lower incidence and cancer deaths. Only colonoscopies were linked curcumin cervical cancer treatment to a decreased risk of getting cancer that cervical cancer treatment started in the proximal colon, […]

  17. Treatments For Colorectal Cancer | Word Scrawl - December 29, 2013

    […] occurs when the cancerous bowel cancer treatment cells are physically removed from the affected area. Colon cancer surgery is the most common […]

  18. Colon Cancer: Symptoms And Treatment Of Colorectal Cancer | Design Mom - December 29, 2013

    […] can also be used to destroy cancer cells or cease their division. The use of drugs to fight cancer is known as chemotherapy. […]

  19. Grape Seed Extract Provides A Natural Treatment Option For Colorectal Cancer | Design Mom - December 29, 2013

    […] a comprehensive EBook explaining how to use Diet, Exercise, Mind and Targeted Supplementation to Haltia Turmeric Serum achieve your weight loss goal. Visit My Optimal Health Resource to continue reading the latest […]

  20. Curcumin Causes Colon Cancer Cells To Self-destruct | Word Scrawl - December 30, 2013

    […] turmeric itself can travel in the body, alkalize it and kill cancer cells in their tracks. colorectal cancer treatment More information cervical mallignant melanoma at […]

  21. Aspirin, Hormone Therapy Combo Can Shorten Lives Of Prostate Cancer Patients | Small Dead Animals - December 30, 2013

    […] prostate cancer, but it can raise the risk of a heart attack . So men who are older or have known curcumin liver cancer treatment coronary risk factors such as diabetes or smoking usually take baby aspirin while undergoing […]

  22. As Gene Therapy Successes Mount, Alliance For Cancer Gene Therapy (acgt) Remains In Vanguard Of Funding Breakthrough Research, Treatments | TheWayThereBlog - December 30, 2013

    […] poised for a significant run in the months and years ahead as the companys platform continues treatment of bowel cancer to be validated by science. But before taking a position, investors should take a look at the […]

  23. Reality On Bravo » Blog Archive » Science Names Dr. Allison’s Md Anderson-led Focus On Cancer Immunotherapy The 2013 Breakthrough Of The Year - December 30, 2013

    […] some. His leadership continues to advance this exciting treatment and underpins the comprehensive how to cure cancer efforts of MD Andersons Moon Shots Program to dramatically reducecancerdeaths, DePinho added. The […]

  24. Grape Seed Extract Provides A Natural Treatment Option For Colorectal Cancer | Her Bad Mother - January 2, 2014

    […] and lifestyle: non-chemo treatments for colon Curcumin Serum […]

  25. Our Gaggle Of Girls : To Prevent Colon Cancer, Get Your Butt To The Doctor - January 3, 2014

    […] a change in bowel habits, diarrhea or a change in weight, experts from the NIH noted. Experts from symptoms of bowel cancer Dana Farber added, A month or more narrowing of the stools, straining, change in stool shape are […]

  26. Our Gaggle Of Girls : A Colon Cancer Treatment Diet - January 5, 2014

    […] that may help fight colorectal cancer. Dairy foods. Calcium, working with vitamin D, may help keep colon cancer at bay. Add low-fat dairy foods and drinks that are rich in calcium to your menu, […]

  27. Treatment For Tingling Extremities | Word Scrawl - January 5, 2014

    […] Haltia Turmeric Serum src=’’ […]

  28. Cancer Among Dogs On The Rise In Coimbatore - Mrs. Fussypants Guide To Life - January 5, 2014

    […] [read] like in the case of many humans, cancer among canines too is usually detected at an advanced stage […]

  29. Curcumin Causes Colon Cancer Cells To Self-destruct | Small Dead Animals - January 7, 2014

    […] my company […]

  30. Reality On Bravo » Blog Archive » Indian Scientists Show The Way Of Fighting Cancer With Plant Molecules - January 8, 2014

    […] Irritable Bowel Syndrome […]

  31. Experts Say Cervical Cancer Can Be Easily Prevented - Mrs. Fussypants Guide To Life - January 9, 2014

    […] the plasma thermogram technology to analyse blood samples. The sample will respond differently to Haltia Turmeric Serum heat depending on the types of proteins contained in the blood. It results in a thermogram – like a […]

  32. Alternative Cancer Treatments: 11 Options To Consider | TheWayThereBlog - January 10, 2014

    […] Music therapy may help relieve pain and control nausea and vomiting. Music therapy is safe and how to cure cancer doesn’t require any musical talent to participate. Many medical centers have certified music […]

  33. Curcumin Useful In The Fight Against Colorectal Cancer | Her Bad Mother - January 11, 2014

    […] on the process by which neurotensin stimulates colon cancer cells to generate IL-8 in detail. more… Neurotensin’s influence, they found, depends on biochemical signaling pathways inside the […]

  34. Alarming News » Blog Archive » Vietnam Successfully Produces Nano Curcumin For Cancer Treatment - January 12, 2014

    […] increase the dissolution in water of normal Curcumin, as Nano Curcumin is 40 times more absorbent, curcumin cancer treatment said Pham Huu Ly from the chemistry institute, adding that it will help improve treatment of a […]

  35. Post-surgical Tests Might Help Spot Colon Cancer’s Return - Mrs. Fussypants Guide To Life - January 17, 2014

    […] who did not receive follow-up screening after their initial surgery, found Dr. John Primrose, at symptoms of bowel cancer the University of Southampton, and colleagues. WEIGH IN: Ask your fitness questions A U.S. expert […]

  36. Our Gaggle Of Girls : Older Cancer Patients Considered ‘too Old For Treatment’ - January 26, 2014

    […] for breast, colon, esophageal, pancreatic, and stomach cancers, according to preliminary studies. When researchers looked at the results of seven population studies, they found that those with […]

  37. Pet/ct And Biomarkers Predict Treatment Response In Metastatic Colon Cancer - Mrs. Fussypants Guide To Life - January 26, 2014

    […] Cancer bowel cancer treatment Alliance works to break down barriers to colon cancer […]

  38. Older Cancer Patients Considered ‘too Old For Treatment’ - Mrs. Fussypants Guide To Life - January 27, 2014

    […] but in general the research looking at cancer protection hasnt shown much of a link. However, click fish oil can do so much for your health, including helping to prevent heart disease or stroke and […]

  39. Alarming News » Blog Archive » Ormc: January Is Cervical Cancer Awareness Month - February 2, 2014

    […] for CYTR? Guided Therapeutics Majlis Kanser Kebangsaan Malaysia (GTHP) has an Approved Cervical Cancer Scan for […]

  40. New Study On Curcumin For Advanced Bowel Cancer | Word Scrawl - March 26, 2014

    […] liver and, three days after being admitted to Leicester Royal Infirmary, he underwent an emergency Curcumin cancer treatment ileostomy to bypass the blockage. “It’s been like a whirlwind,” said Colin who […]

  41. Breast Cancer ‘personal Drugs’ Hope After Gene Study | Small Dead Animals - April 2, 2014

    […] and conducted in collaboration with colleagues from Spain, Brazil and the UK. He said the work liver cancer treatment involved a genetic “trick” to study how one genetic error manifested itself in two […]

  42. How Does Colon Cancer Develop? | Word Scrawl - April 2, 2014

    […] bowel cancer treatment style=”clear:both”>Yes, you can beat colorectal […]

  43. Alternative Medicine For Cancer Treatment – Cancer Center – Everyday Health | Word Scrawl - April 6, 2014

    […] Scorsetti, director of the hospital's radiotherapy and Haltia Turmeric Serum radiosurgery department. "In particular, Edge allows us to start new protocols for treating […]

  44. Curcumin, Special Peptides Boost Cancer-blocking Pias3 To Neutralize Cancer-activating Stat3 In Mesothelioma | Melanie Morgan - September 19, 2014

    […] scientific knowledge for all cancer. Our findings beg the question of what role PIAS3 could play in read here limiting STAT3 activation in other cancers as well, Dowlati said. There is an opportunity to extend […]

  45. Listeria Fears Spark Nationwide Fruit Recall | Martini’s Persistence & A Smile - September 23, 2014

    […] Recall Came After Internal Testing At The Packing House In Tulare […]

  46. New Research Adds Spice To Curcumin’s Health-promoting Benefits — Sciencedaily | Martini’s Persistence & A Smile - November 12, 2014

    […] observed in many diseases,” Young said. “The distinction will then be in the amount given — perhaps a low dose for daily prevention and higher doses for disease […]

  47. New Gp Surgery Opens In The Heart Of Wimbledon | Melanie Morgan - January 13, 2015

    […] GP Surgery has newly opened in the heart of Wimbledon in response to patient concerns about NHS GP inaccessibility. With increased strain on GP services over the winter period waiting times for a […]

  48. Curcumin: This Compound In Turmeric Can Boost Your Heart Health – Health | The Star Online | Melanie Morgan - February 10, 2015

    […] containing one gram of curcumin powder, and the other half were given similar looking pills with find out gynecological cancers treatment details no curcumin inside. All the participants took the supplements every day for eight weeks. The […]

Leave a Reply